Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation

@article{Gais2006SleepdependentSI,
  title={Sleep-dependent surges in growth hormone do not contribute to sleep-dependent memory consolidation},
  author={Steffen Gais and Philipp H{\"u}llemann and Manfred Hallschmid and Jan Born},
  journal={Psychoneuroendocrinology},
  year={2006},
  volume={31},
  pages={786-791}
}

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References

SHOWING 1-10 OF 19 REFERENCES
Memory consolidation in human sleep depends on inhibition of glucocorticoid release.
TLDR
It is shown in healthy humans that an inhibition of glucocorticoid release from the adrenals serves to support declarative memory consolidation during sleep, and blocking mineralocortioid receptors by canrenoate did not affect memory, suggesting inactivation of glucOCorticoids receptors to be the essential prerequisite for memory consolidationduring early sleep.
Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
  • S. Gais, J. Born
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Increasing central nervous cholinergic activation during SWS-rich sleep by posttrial infusion of 0.75 mg of the cholinesterase inhibitor physostigmine completely blocked SWs-related consolidation of declarative memories for word pairs in human subjects, in line with predictions that a low Cholinergic tone duringSWS is essential forDeclarative memory consolidation.
Declarative memory consolidation: mechanisms acting during human sleep.
TLDR
It is shown that declarative memory benefits mainly from sleep periods dominated by SWS, whereas there is no consistent benefit of this memory from periods rich in rapid eye movement (REM) sleep.
Sleep-Dependent Learning and Memory Consolidation
Hypothalamus-pituitary-adrenal activity during human sleep: a coordinating role for the limbic hippocampal system.
  • J. Born, H. Fehm
  • Biology, Psychology
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 1998
TLDR
This review focuses on experiments in humans examining the regulation of the hypothalamo-pituitary-adrenal (HPA) system during nocturnal sleep, and suggests that this trias of symptoms may benefit from intranasal treatment with neuropeptides like vasopressin and growth hormone releasing hormone.
Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory
TLDR
The experiments for the first time dissociate specific effects of early and late sleep on two principal types of memory, declarative and procedural, in humans, and the benefit from sleep on recall depended on the phase of sleep and on the type of memory.
Neuromodulation: acetylcholine and memory consolidation
  • M. Hasselmo
  • Biology, Psychology
    Trends in Cognitive Sciences
  • 1999
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
  • F. Nyberg
  • Biology, Medicine
    Frontiers in Neuroendocrinology
  • 2000
TLDR
Support that the CNS is a target for GH emerges from observations indicating that the hormone may cross the blood-brain barrier (BBB) and from studies confirming the presence of GH receptors in the brain.
Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls.
TLDR
The effects of episodic GHRH administration upon SWS, GH and cortisol secretion were opposite to those previously reported for corticotropin-releasing hormone, which supports the view that neuroregulation of human sleep involves an interaction of central G HRH and corticotropic hormone.
...
...