Sleep changes produced by destruction of medial septal neurons in rats.

Changes in sleep-wakefulness were studied in male Wistar rats after destruction of the medial septal neurons with NMDA. Electroencephalogram, electromyogram and electrooculogram were recorded for 24 h prior to the destruction of the medial septum, and 7, 14 and 21 days after the destruction. There was a decrease in the total amount of slow wave sleep and… (More)