Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities

@article{McNicholas2007SleepAA,
  title={Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities},
  author={Walter T. McNicholas and Marisa R Bonsignore},
  journal={European Respiratory Journal},
  year={2007},
  volume={29},
  pages={156 - 178}
}
Considerable evidence is available in support of an independent association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular disease, which is particularly strong for systemic arterial hypertension and growing for ischaemic heart disease, stroke, heart failure, atrial fibrillation and cardiac sudden death. The pathogenesis of cardiovascular disease in OSAS is not completely understood but likely to be multifactorial, involving a diverse range of mechanisms including… Expand
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There is increasing evidence that adequate CPAP therapy leads to a significant reduction in cardiovascular morbidity, and continuous positive airway pressure and oral appliance therapy are the two treatments for OSA whose effects on cardiovascular endpoints have been assessed in randomised trials. Expand
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A PubMed search of all the recent literature relating to OSA and co-morbidities was undertaken to critically evaluate the potential relationships and possible benefit of continuous positive airway pressure (CPAP) therapy. Expand
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  • Medicine
  • Journal of thoracic disease
  • 2018
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In this review, the available evidence of the pathophysiological mechanisms of CVD in OSA is explored with a specific emphasis on IH, recurrent arousals and intrathoracic pressure swings as the main pathophysiology triggers. Expand
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Data in OSA models and animal models are now available that support the link between sleep apnoea and atherosclerosis and dysmetabolism, and there is a need to pay closer clinical attention to these conditions. Expand
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There are now convincing data regarding the association between hypertension, arrhythmias, coronary heart disease, heart failure, increased cardiovascular mortality and sleep apnoea, evidenced in patients and supported by experimental data obtained in intermittent hypoxia. Expand
Inflammatory cardiovascular risk markers in obstructive sleep apnoea syndrome.
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