Sleep apnea, norepinephrine-release rate, and daytime hypertension.

  title={Sleep apnea, norepinephrine-release rate, and daytime hypertension.},
  author={Michael G. Ziegler and Richard A. Nelesen and Paul J. Mills and Sonia Ancoli-Israel and Brian P Kennedy and Joel E. Dimsdale},
  volume={20 3},
Patients with obstructive sleep apnea (OSA) are often hypertensive, and both apneics and hypertensives are reported to have increased sympathetic nerve activity. We measured plasma norepinephrine (NE) levels, clearance, and release rate among 65 subjects who breathed room air, a hypoxic gas mixture, and the hypoxic mixture combined with intermittent breath holding. Apneics' plasma NE across all three breathing conditions was 307 pg/ml compared with the non-apneics' level of 248 pg/ml (p = 0.017… CONTINUE READING