Sleep and the single neuron: the role of global slow oscillations in individual cell rest

  title={Sleep and the single neuron: the role of global slow oscillations in individual cell rest},
  author={Vladyslav V Vyazovskiy and Kenneth D Harris},
  journal={Nature Reviews Neuroscience},
Sleep is universal in animals, but its specific functions remain elusive. We propose that sleep's primary function is to allow individual neurons to perform prophylactic cellular maintenance. Just as muscle cells must rest after strenuous exercise to prevent long-term damage, brain cells must rest after intense synaptic activity. We suggest that periods of reduced synaptic input ('off periods' or 'down states') are necessary for such maintenance. This in turn requires a state of globally… CONTINUE READING
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Publications referenced by this paper.
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Individual differences in white matter diffusion affect sleep oscillations

  • G Piantoni
  • J. Neurosci
  • 2013

the case of sleep

  • Blumberg, M. S. Homology, correspondence, continuity across development
  • Dev. Psychobiol. 55, 92–100
  • 2013

Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons

  • Wang, A T.
  • Science 337,
  • 2012

Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase

  • Lo, C J.
  • PLoS ONE 7,
  • 2012