Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration

@article{Tononi2014SleepAT,
  title={Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration},
  author={G. Tononi and C. Cirelli},
  journal={Neuron},
  year={2014},
  volume={81},
  pages={12-34}
}
Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain need to disconnect from the environment for hours every day? The synaptic homeostasis hypothesis (SHY) proposes that sleep is the price the brain pays for plasticity. During a waking episode, learning statistical regularities about the current environment requires strengthening connections throughout the brain. This increases cellular needs for energy and supplies, decreases signal-to-noise ratios, and… Expand
Sleep and synaptic down‐selection
Experience-dependent upregulation of multiple plasticity factors in the hippocampus during early REM sleep
Synaptic Homeostasis and Restructuring across the Sleep-Wake Cycle
Computational models of memory consolidation and long-term synaptic plasticity during sleep
Linking the need to sleep with synaptic function
Sleep and synaptic homeostasis.
Sleep slow oscillation and plasticity
Evidence for sleep-dependent synaptic renormalization in mouse pups
Primed to Sleep: The Dynamics of Synaptic Plasticity Across Brain States
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 286 REFERENCES
Time to Be SHY? Some Comments on Sleep and Synaptic Homeostasis
Sleep function and synaptic homeostasis.
Synaptic potentiation and sleep need: clues from molecular and electrophysiological studies.
Cognitive neuroscience of sleep.
Erasing Synapses in Sleep: Is It Time to Be SHY?
  • M. Frank
  • Psychology, Medicine
  • Neural plasticity
  • 2012
The memory function of sleep
Sleep and synaptic homeostasis: a hypothesis
Sleep and synaptic renormalization: a computational study.
Concurrent Synaptic and Systems Memory Consolidation during Sleep
...
1
2
3
4
5
...