Sleep and sleep electroencephalogram in depressed patients treated with phenelzine.

  title={Sleep and sleep electroencephalogram in depressed patients treated with phenelzine.},
  author={H P Landolt and E B Raimo and B J Schnierow and John Kelsoe and Mark Hyman Rapaport and J. Christian Gillin},
  journal={Archives of general psychiatry},
  volume={58 3},
BACKGROUND The beneficial effect of antidepressant interventions has been proposed to depend on suppression of rapid eye movement (REM) sleep or inhibition of electroencephalographic (EEG) slow-wave activity (SWA) in non-REM sleep. Use of the monoamine oxidase inhibitor phenelzine sulfate can eliminate REM sleep. We studied the relation between REM sleep suppression and antidepressant response and the effect of phenelzine therapy on sleep EEG power spectra. METHODS Open-labeled prescriptions… CONTINUE READING


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