Sleep and sleep disturbances: biological basis and clinical implications

  title={Sleep and sleep disturbances: biological basis and clinical implications},
  author={Nava Zisapel},
  journal={Cellular and Molecular Life Sciences},
  • N. Zisapel
  • Published 15 March 2007
  • Biology, Psychology, Medicine
  • Cellular and Molecular Life Sciences
Abstract.Sleep is a neurochemical process involving sleep promoting and arousal centers in the brain. Sleep performs an essential restorative function and facilitates memory consolidation in humans. The remarkably standardized bouts of consolidated sleep at night and daytime wakefulness reflect an interaction between the homeostatic sleep need that is manifested by increase in sleep propensity after sleep deprivation and decrease during sleep and the circadian pacemaker. Melatonin, the hormone… 
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