Sleep and depression — results from psychobiological studies: an overview

  title={Sleep and depression — results from psychobiological studies: an overview},
  author={Dieter Riemann and Mathias Berger and Ulrich Voderholzer},
  journal={Biological Psychology},

Sleep, insomnia, and depression

The question is: can the early and adequate treatment of insomnia prevent depression, and current understanding about sleep regulatory mechanisms with knowledge about changes in physiology due to depression are linked.

Schlaf, Depression und insomnische Beschwerden

It is also worthwhile mentioning that specific cognitive behavioral interventions for insomniac symptoms, such as sleep hygiene, sleep-wake rhythm structuring and cognitive techniques to reduce nocturnal rumination are very effective in the treatment of insomnia.

Significance of REM Sleep in Depression: Effects on Neurogenesis

High risk studies including healthy relatives of patients with depression have demonstrated that REM sleep, particularly REM density changes, are present before the disorder’s onset and predict its development, suggesting changes in neurogenesis might be linked to the pathophysiology of depression.

Sleep and sleep disorders in depression

For patients with depression who experience insomnia, antidepressants, hypnotics, and cognitive behavioral therapy can be used effectively to relieve insomnia, but since pharmacotherapy for depression and insomnia might degrade sleep quality and/or cause (or aggravate) obstructive sleep apnea, restless legs syndrome, and REM sleep behavior disorder, medication should be used cautiously.

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Work by others and the own studies indicate that sleep deprivation and a phase advance of the sleep period can be used to treat bipolar patients during the depressed phase, and the risk of a switch into hypomania or mania does not seem to be more pronounced than the risk with typical pharmacological antidepressant treatment.

Pathophysiology of depression: Role of sleep and the melatonergic system

Sleep in obsessive compulsive disorder

This study indicates that neurobiological disturbances are different in primary OCD as compared with primary depression.

Sleep and psychiatric diseases.




Improvement of depression by REM sleep deprivation. New findings and a theory.

It is suggested that the depressive abnormalities represent a "damaged," weakened sleep cycle "oscillator" and its correlate, a circadian rhythm disturbance, and that REM sleep deprivation improved depression to the extent that it stimulated the oscillator and corrected one manifestation of the circadian rhythm disturbances.

EEG sleep in depression and in remission and the REM sleep response to the cholinergic agonist RS 86.

  • D. RiemannM. Berger
  • Psychology, Medicine
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1989

Electroencephalographic sleep profiles before and after cognitive behavior therapy of depression.

The electroencephalographic sleep correlates of depression can be disaggregated into state-independent and partially reversible subgroups, and persistent sleep disturbances in remitted patients may have ominous prognostic implications.

Patterns of insomnia in depressive states

  • J. Hinton
  • Psychology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1963
The purpose of the present study was to investigate the sleep and motility distribution of depressed patients and see if they were related to features of the depressive state.

The cholinergic rapid eye movement sleep induction test with RS-86. State or trait marker of depression?

The application of this compound before sleep led to a significantly faster induction of REM sleep at the beginning of the night in patients with major depressive disorders compared with healthy subjects and patients with other nondepressive psychiatric diseases, such as eating disorders.

The effects of total sleep deprivation and subsequent treatment with clomipramine on depressive symptoms and sleep electroencephalography in patients with a major depressive disorder *

TSD did not differentially influence the sleep EEG (responders vs nonresponders): responders tended, however, to show a more classical depressive sleep pattern prior to TSD, and clomipramine profoundly suppressed rapid eye movement (REM) sleep.