Sleep and circadian rhythm dysregulation in schizophrenia

@article{Monti2013SleepAC,
  title={Sleep and circadian rhythm dysregulation in schizophrenia},
  author={Jaime M. Monti and Ahmed S. Bahammam and Seithikurippu R. Pandi-Perumal and Vivien Bromundt and David Warren Spence and Daniel P. Cardinali and Gregory M. Brown},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2013},
  volume={43},
  pages={209-216}
}
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125 Citations

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Evidence that sleep and circadian rhythm disturbances constitute a fundamental component of schizophrenia is reviewed, as supported by both human studies and animal models with genetic mutations related to schizophrenia.
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A neurodevelopmental diathesis–stress model is posited to highlight potential research targets and mechanisms through which vulnerability, biological/psychosocial stress, and adolescent neuromaturational factors may contribute to both sleep dysfunction and development of psychosis in at-risk youth.
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The results indicate that the STOP null mutation in mice altered the regulation of sleep/wake physiology and activity rhythm expression, but did not grossly disrupt circadian mechanisms.
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