Sleep and circadian rhythm dysregulation in schizophrenia
@article{Monti2013SleepAC, title={Sleep and circadian rhythm dysregulation in schizophrenia}, author={Jaime M. Monti and Ahmed S. Bahammam and Seithikurippu R. Pandi-Perumal and Vivien Bromundt and David Warren Spence and Daniel P. Cardinali and Gregory M. Brown}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2013}, volume={43}, pages={209-216} }
125 Citations
Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis
- Psychology, MedicineReviews in the neurosciences
- 2016
Evidence of sleep playing an important role in psychosis predominantly mediated by dopaminergic pathways is presented, suggesting that treatment of circadian disturbance may be a useful target in improving the lives and symptoms of patients with schizophrenia.
Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders
- Psychology, BiologyInternational journal of molecular sciences
- 2017
The role of clock genes and altered sleep–wake rhythms in the development of psychiatric disorders is clarified and promising avenues for early detection and therapeutic intervention in psychiatric disorders are opened.
Disruptions of Sleep/Wake Patterns in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
- Psychology, BiologySchizophrenia bulletin
- 2016
It is indicated that STOP null mice sleep less overall, and their sleep and wake periods are more fragmented than those of WT mice, which are consistent with the sleep patterns observed in patients with schizophrenia.
Sleep therapeutics and neuropsychiatric illness
- Psychology, MedicineNeuropsychopharmacology
- 2019
Alterations in sleep are extremely common in patients with neuropsychiatric illness. In addition, sleep disorders such as insomnia, obstructive sleep apnea, rapid eye movement sleep behavior…
Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1
- Psychology, BiologyNeuroscience Research
- 2016
Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?
- Psychology, MedicineJournal of biological rhythms
- 2020
Evidence that sleep and circadian rhythm disturbances constitute a fundamental component of schizophrenia is reviewed, as supported by both human studies and animal models with genetic mutations related to schizophrenia.
Schizophrenia and sleep disorders: links, risks, and management challenges
- Psychology, MedicineNature and science of sleep
- 2017
The present review will systematically examine the literature on sleep disorders and schizophrenia, focusing on studies related to links between distinct sleep Disorders and schizophrenia; risks unique to patients with a comorbid sleep disorder; and management challenges and strategies.
Sleep Dysfunction Prior to the Onset of Schizophrenia: A Review and Neurodevelopmental Diathesis–Stress Conceptualization
- Psychology, Medicine
- 2013
A neurodevelopmental diathesis–stress model is posited to highlight potential research targets and mechanisms through which vulnerability, biological/psychosocial stress, and adolescent neuromaturational factors may contribute to both sleep dysfunction and development of psychosis in at-risk youth.
Altered Circadian Activity and Sleep/Wake Rhythms in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
- Psychology, BiologySleep
- 2020
The results indicate that the STOP null mutation in mice altered the regulation of sleep/wake physiology and activity rhythm expression, but did not grossly disrupt circadian mechanisms.
Sleep Disturbances in Schizophrenia.
- Psychology, MedicineThe Psychiatric clinics of North America
- 2015
References
SHOWING 1-10 OF 138 REFERENCES
Sleep and circadian rhythm disruption in schizophrenia†
- Psychology, MedicineThe British journal of psychiatry : the journal of mental science
- 2012
Severe circadian sleep/wake disruptions exist despite stability in mood, mental state and newer antipsychotic treatment, and cannot be explained by the individuals' level of everyday function.
Sleep in schizophrenia patients and the effects of antipsychotic drugs.
- Psychology, MedicineSleep medicine reviews
- 2004
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
- Psychology, BiologyNature Reviews Neuroscience
- 2010
It is proposed that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms.
Sleep Disturbances in Patients with Schizophrenia
- Psychology, MedicineCNS drugs
- 2008
It appears possible that the high-potency drugs exert their effects on sleep in schizophrenic patients, for the most part, in an indirect way by suppressing stressful psychotic symptomatology.
Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia
- Psychology, MedicineSchizophrenia Research
- 2003
Sleep in Schizophrenia: A Polysomnographic Study on Drug-Naive Patients
- Psychology, MedicineNeuropsychopharmacology
- 1997
Electroencephalographic sleep in schizophrenia: a critical review.
- Psychology, MedicineComprehensive psychiatry
- 1990
A schizophrenic patient with an arrhythmic circadian rest-activity cycle
- Psychology, MedicinePsychiatry Research
- 1997
Disrupted Circadian Rhythms in a Mouse Model of Schizophrenia
- Psychology, BiologyCurrent Biology
- 2012
Melatonin improves sleep quality of patients with chronic schizophrenia.
- Medicine, PsychologyThe Journal of clinical psychiatry
- 2000
Melatonin improves sleep efficiency in patients with schizophrenia whose sleep quality is low and significantly improved rest-derived sleep efficiency compared with placebo in this population.