Sleep and circadian rhythm dysregulation in schizophrenia

@article{Monti2013SleepAC,
  title={Sleep and circadian rhythm dysregulation in schizophrenia},
  author={Jaime M. Monti and Ahmed S Bahammam and Seithikurippu R Pandi-Perumal and Vivien Bromundt and David Warren Spence and Daniel Pedro Cardinali and Gregory M Brown},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2013},
  volume={43},
  pages={209-216}
}
Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to… Expand
Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis
  • N. Yates
  • Medicine, Psychology
  • Reviews in the neurosciences
  • 2016
TLDR
Evidence of sleep playing an important role in psychosis predominantly mediated by dopaminergic pathways is presented, suggesting that treatment of circadian disturbance may be a useful target in improving the lives and symptoms of patients with schizophrenia. Expand
Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders
TLDR
The role of clock genes and altered sleep–wake rhythms in the development of psychiatric disorders is clarified and promising avenues for early detection and therapeutic intervention in psychiatric disorders are opened. Expand
Disruptions of Sleep/Wake Patterns in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
TLDR
It is indicated that STOP null mice sleep less overall, and their sleep and wake periods are more fragmented than those of WT mice, which are consistent with the sleep patterns observed in patients with schizophrenia. Expand
Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice
TLDR
The results suggest that Egr3-/- mice retain control over the circadian timekeeping of sleep and wake, while showing impaired sleep, raising the possibility that SCRD and sleep and circadian rhythm disruption may be 2 separate disorders in the schizophrenia population requiring different treatment strategies. Expand
Sleep therapeutics and neuropsychiatric illness
Alterations in sleep are extremely common in patients with neuropsychiatric illness. In addition, sleep disorders such as insomnia, obstructive sleep apnea, rapid eye movement sleep behaviorExpand
Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1
TLDR
It is suggested that DISC1 may be involved in sleep regulation by monitoring wheel running activity under normal 24-h light:dark conditions and in constant darkness and assessing sleep duration and quality in the DISC 1 mice. Expand
Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?
TLDR
Evidence that sleep and circadian rhythm disturbances constitute a fundamental component of schizophrenia is reviewed, as supported by both human studies and animal models with genetic mutations related to schizophrenia. Expand
Schizophrenia and sleep disorders: links, risks, and management challenges
TLDR
The present review will systematically examine the literature on sleep disorders and schizophrenia, focusing on studies related to links between distinct sleep Disorders and schizophrenia; risks unique to patients with a comorbid sleep disorder; and management challenges and strategies. Expand
Sleep Dysfunction Prior to the Onset of Schizophrenia: A Review and Neurodevelopmental Diathesis–Stress Conceptualization
Sleep dysfunction is a pervasive symptom in schizophrenia, yet little is known regarding the extent to which problematic sleep is present prior to illness onset. Results from an online databaseExpand
Altered Circadian Activity and Sleep/Wake Rhythms in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
TLDR
The results indicate that the STOP null mutation in mice altered the regulation of sleep/wake physiology and activity rhythm expression, but did not grossly disrupt circadian mechanisms. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 139 REFERENCES
Sleep and circadian rhythm disruption in schizophrenia†
TLDR
Severe circadian sleep/wake disruptions exist despite stability in mood, mental state and newer antipsychotic treatment, and cannot be explained by the individuals' level of everyday function. Expand
Sleep in schizophrenia patients and the effects of antipsychotic drugs.
TLDR
The sleep disturbances of either never-medicated or previously treated schizophrenia patients are characterized by a sleep-onset and maintenance insomnia, and the atypical antipsychotics olanzapine, risperidone, and clozapine significantly increase total sleep time and stage 2 sleep. Expand
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
TLDR
It is proposed that brain disorders and abnormal sleep have a common mechanistic origin and that many co-morbid pathologies that are found in brain disease arise from a destabilization of sleep mechanisms. Expand
Sleep Disturbances in Patients with Schizophrenia
  • S. Cohrs
  • Psychology, Medicine
  • CNS drugs
  • 2008
TLDR
It appears possible that the high-potency drugs exert their effects on sleep in schizophrenic patients, for the most part, in an indirect way by suppressing stressful psychotic symptomatology. Expand
Sleep–wake cycles and cognitive functioning in schizophrenia
TLDR
Consolidated circadian rhythms and sleep may be a prerequisite for adequate cognitive functioning in individuals with schizophrenia. Expand
Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia
TLDR
It is confirmed that the duration of stage 4 and REM sleep latency are reduced in first episode and neuroleptic-naive patients with schizophrenia and the fact that measures of REM sleep correlate with clinical scales of schizophrenia suggests that REM sleep physiology shares common substrates with symptoms of this disease. Expand
Sleep in Schizophrenia: A Polysomnographic Study on Drug-Naive Patients
TLDR
The results indicate that the commonly reported SWS and REM sleep changes in schizophrenia reflect the remnant of prior neuroleptic treatment rather than the pathophysiology of the disorder itself. Expand
Electroencephalographic sleep in schizophrenia: a critical review.
TLDR
It appears that reduced slow wave sleep may be related to a neurodevelopmental disorder related to the defect state in schizophrenia, and the pathophysiological significance of the defective REM rebound and the REM sleep abnormalities in schizophrenia remain uncertain. Expand
A schizophrenic patient with an arrhythmic circadian rest-activity cycle
TLDR
A haloperidol-treated patient with chronic schizophrenia had a near-arrhythmic circadian rest-activity cycle, whereas rhythms of 6-sulphatoxy-melatonin and core body temperature were of normal amplitude and phase-advanced, while switching treatment to the atypical neuroleptic clozapine improved both the circadian organization of the rest- activity cycle and the patient's clinical state. Expand
Disrupted Circadian Rhythms in a Mouse Model of Schizophrenia
TLDR
The circadian phenotype of blind-drunk mice is investigated to suggest that the Bdr circadian phenotype arises from a disruption of synaptic connectivity within the SCN that alters critical output signals, providing a link between disruption of circadian activity cycles and synaptic dysfunction in a model of neuropsychiatric disease. Expand
...
1
2
3
4
5
...