Sleep and Its Modulation by Drugs That Affect GABA(A) Receptor Function.

@article{Lancel1999SleepAI,
  title={Sleep and Its Modulation by Drugs That Affect GABA(A) Receptor Function.},
  author={Lancel and Steiger},
  journal={Angewandte Chemie},
  year={1999},
  volume={38 19},
  pages={
          2852-2864
        }
}
Most sleeping pills are made up of chemical compounds that are ligands for allosteric modulatory binding sites on the GABA(A) receptor. Polysomnographic studies demonstrate that these hypnotics effectively increase the ability to fall and to stay asleep, but disrupt the physiological sleep profile (typical electroencephalograms (EEG) for the awake state and the different states of sleep are shown). Hence, there is an urgent need for sleep-promoting substances with a different mechanism of… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

COMMENTARY GABA MECHANISMS AND SLEEP

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

VIEW 1 EXCERPT
CITES BACKGROUND

Neuroscience-driven discovery and development of sleep therapeutics.

VIEW 2 EXCERPTS
CITES BACKGROUND

A double dissociation of memory impairments in major depression.

VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND

Role of GABAA receptors in cognition.

  • Hanns Möhler
  • Biology, Medicine
  • Biochemical Society transactions
  • 2009

GABAA receptor diversity and pharmacology

VIEW 2 EXCERPTS
CITES BACKGROUND