Sleep and Adenosine: Human Studies

  title={Sleep and Adenosine: Human Studies},
  author={Tarja Porkka-Heiskanen},
Adenosine, through A1 receptors, acts as an inhibitory neuromodulator in the central nervous system. It is also directly linked to the energy metabolism of cells. It codes for energy depletion: adenosine levels increase as sign of problems in energy balance. Extracellular adenosine levels increase as response to prolonged wakefulness, starting locally in the basal forebrain area and later in the cortex. The increased extracellular adenosine concentrations increase signaling through A1 receptors… CONTINUE READING