Sleep Suppression after Basal Forebrain Lesions in the Cat

@article{McGinty1968SleepSA,
  title={Sleep Suppression after Basal Forebrain Lesions in the Cat},
  author={Dennis McGinty and Maurice B. Sterman},
  journal={Science},
  year={1968},
  volume={160},
  pages={1253 - 1255}
}
Large bilateral preoptic lesions produced complete sleeplessness in two cats. In eight additional cats, similar but smaller lesions resulted in a significant reduction of quiet (slow-wave) sleep by 55 to 73 percent, and active (paradoxical) sleep by 80 to 100 percent. These values were determined by pre- and postlesion 22-hour continuous observations. Complete sleeplessness was followed by lethal exhaustion within a few days, whereas incomplete sleeplessness persisted at maximum levels for 2 to… 

Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions.

The NMDA lesion of the mPOA produced long-lasting insomnia with marked reduction in the deeper stages of sleep, including paradoxical sleep, and body weights of the rats were reduced even without any change in food and water intake.

Effect of amphetamine and pentobarbital on sleep-wake patterns of cats with basal forebrain lesions

It is hypothesized that pentobarbital mimics the normal inhibitory influence of the intact forebrain and either induces or facilitates ‘normal’ sleep patterns in cats with forebrain lesions.

Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle.

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