Sleep Suppression after Basal Forebrain Lesions in the Cat

  title={Sleep Suppression after Basal Forebrain Lesions in the Cat},
  author={Dennis McGinty and Maurice B. Sterman},
  pages={1253 - 1255}
Large bilateral preoptic lesions produced complete sleeplessness in two cats. In eight additional cats, similar but smaller lesions resulted in a significant reduction of quiet (slow-wave) sleep by 55 to 73 percent, and active (paradoxical) sleep by 80 to 100 percent. These values were determined by pre- and postlesion 22-hour continuous observations. Complete sleeplessness was followed by lethal exhaustion within a few days, whereas incomplete sleeplessness persisted at maximum levels for 2 to… 

Effect of NMDA lesion of the medial preoptic neurons on sleep and other functions.

The NMDA lesion of the mPOA produced long-lasting insomnia with marked reduction in the deeper stages of sleep, including paradoxical sleep, and body weights of the rats were reduced even without any change in food and water intake.

Effect of amphetamine and pentobarbital on sleep-wake patterns of cats with basal forebrain lesions

It is hypothesized that pentobarbital mimics the normal inhibitory influence of the intact forebrain and either induces or facilitates ‘normal’ sleep patterns in cats with forebrain lesions.

Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle.




Behavioral and polygraphic study of "sleep" and "wakefulness" in chronic decerebrate cats.

  • J. Villablanca
  • Psychology, Biology
    Electroencephalography and clinical neurophysiology
  • 1966

Effects of lesions of the rostral thalamus on brain waves and behavior in cats.


Observations of the periodic EEG and behavioral sleep patterns of Macaca mulatta monkeys are reported, finding characteristic alterations in a number of autonomic and somatic motor functions to correlate with the EEG pattern.


Behavioral and EEG changes following chronic brain stem lesions in the cat.

Circadian sleep and waking patterns in the laboratory cat.

Rate of recovery of functioning in cats with rostral reticular lesions; an experimental study.

  • J. Adametz
  • Psychology, Biology
    Journal of neurosurgery
  • 1959
Experiments on 9 monkeys reported by French and Magoun 6 appeared generally to confirm these results so far as destruction of the reticular activating system and the associated behavioral deficits are concerned.

Lesions in the Medial Forebrain Bundle: Delayed Effects on Sensitivity to Electric Shock

Rats with bilateral lesions in the medial forebrain bundle demonstrate both an increased sensitivity to electric shock, as reflected by a lowered jump threshold, and a decrease in the concentration of serotonin in the brain, which is suggested to be due to a central denervation supersensitivity.