Sleep Spindles
@article{Lthi2014SleepS, title={Sleep Spindles}, author={Anita L{\"u}thi}, journal={The Neuroscientist}, year={2014}, volume={20}, pages={243 - 256} }
Sleep spindles are extensively studied electroencephalographic rhythms that recur periodically during non–rapid eye movement sleep and that are associated with rhythmic discharges of neurons throughout the thalamocortical system. Their occurrence thus constrains many aspects of the communication between thalamus and cortex, ranging from sensory transmission, to cortical plasticity and learning, to development and disease. I review these functional aspects in conjunction with novel findings on…
100 Citations
Oscillating circuitries in the sleeping brain
- Biology, PsychologyNature Reviews Neuroscience
- 2019
Improved understanding of the neurobiological mechanisms that orchestrate sleep-related oscillatory activities are expected to generate further insight into the delineation of sleep states and their functions.
Cortical circuit activity underlying sleep slow oscillations and spindles
- BiologyProceedings of the National Academy of Sciences
- 2018
When spindles are nested in slow oscillation upstates, maximum Pyr activity appears to concur with strong perisomatic inhibition of Pyr cells via PV-Ins and low dendritic inhibition via SOM-Ins (i.e., conditions that might optimize synaptic plasticity within local cortical circuits).
Local sleep spindle modulations in relation to specific memory cues
- Biology, PsychologyNeuroImage
- 2014
Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity
- BiologyNature Reviews Neuroscience
- 2018
Thalamic oscillations of low-vigilance states have a plasticity function that, through modifications of synaptic strength and cellular excitability in local neuronal assemblies, can shape ongoing oscillations during inattention and NREM sleep and may potentially reconfigure thalamic networks for faithful information processing during attentive wakefulness.
Sleep spindle and slow wave abnormalities in schizophrenia and other psychotic disorders: Recent findings and future directions
- Psychology, MedicineSchizophrenia Research
- 2020
The laminar profile of sleep spindles in humans
- BiologybioRxiv
- 2019
The results indicate that extremely local spindles may occur in any cortical layer, but co-occurrence at other locations becomes likelier with increasing amplitude and the relatively large spindle detected on ECoG channels have a stereotypical laminar profile.
Spatiotemporal characteristics of sleep spindles depend on cortical location
- BiologyNeuroImage
- 2017
Cortical reactivations during sleep spindles following declarative learning
- Biology, PsychologyNeuroImage
- 2019
Neuroimaging of Brain Oscillations During Human Sleep
- Biology, Psychology
- 2020
Neuroimaging studies showed that neuronal oscillations of sleep regulate the interplay between the sleeping brain and external stimulations, and highlighted the role of spindles in sleep-dependent memory consolidation.
Coupling of gamma band activity to sleep spindle oscillations – a combined EEG/MEG study
- Biology, Materials ScienceNeuroImage
- 2021
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In vivo photostimulation of the thalamic reticular nucleus of mice is used to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles, indicating a role for the thalamocortical circuit in sleep regulation.
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It is found that although the propagation of spindles depended on synaptic interaction within the thalamus, the initiation and termination of spindle sequences critically involved corticothalamic influences.
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The learning of a motor task is known to be improved by sleep, and sleep spindles are thought to facilitate this learning by enabling synaptic plasticity. In this study subjects implanted with…
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- BiologyProceedings of the National Academy of Sciences
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