Sleep Profile in Patients With Chronic Opioid Abuse: A Polysomnographic Evaluation in an Egyptian Sample

  title={Sleep Profile in Patients With Chronic Opioid Abuse: A Polysomnographic Evaluation in an Egyptian Sample},
  author={Tarek Asaad and Mohamed H. Ghanem and Afaf M. Abdel Samee and Mahmood M. El–Habiby},
  journal={Addictive Disorders \& Their Treatment},
BackgroundSleep disturbances occur in various stages of substance abuse, which might have a significant impact on the treatment success. Despite this fact, the number of researches studying sleep in substance abuse patients is relatively scarce. ObjectivesTo study the profile of sleep in opioid abusers, after the period of detoxification, highlighting whether there is a remote effect of opioid abuse on sleep or not, exploring the nature of such sleep disturbances, if present. MethodologyThe… 

Sleep Profile in Opioid Dependence: A Polysomnographic Case–Control Study

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The sleep problems in buprenorphine-maintained patients seem to be independent of substance use and treatment-related attributes, and no significant difference was found between the 2 groups.

The Relevance of Dual Diagnoses among Drug-Dependent Patients with Sleep Disorders

There is evidence of a harmful association between dual disorder and sleep disorders, and outpatients had more difficulty falling asleep because, in many cases, they had not previously sought any medical assistance.

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Subjective sleep complaints in patients attending a substance use disorder clinic.

Sleep problems are common amongst patients attending the opioid replacement treatment programme and measures to ensure a holistic management of complaints are suggested.

Crosstalk between Sleep Disturbance and Opioid Use Disorder: A Narrative Review

The effects of sleep problems on the occurrence of unpleasant consequences in addiction management, such as craving and relapse in OCD patients, were highlighted.

A narrative review: The effects of opioids on sleep disordered breathing in chronic pain patients and methadone maintained patients.

CSA and OSA are common in MMPs and chronic pain patients on opioids, and higher opioid doses appear to be a risk factor for CSA, and to a lesser extent OSA.

Effects of abstinence from opioids on self-reported craving and sleep

Abstract Abstinence-based treatment of opioid use disorder has always been faced with the probability of an increase in craving, which potentially results in relapse. Moreover, sleep problems are

The Sociodemographic and Clinical Characteristics of Tramadol Dependence Among Egyptians and Their Relationship to the Associated Insomnia

It is found that insomnia is common in subjects suffering from tramadol dependence and is associated with dose, duration, and severity of tramadols dependence.



Variables associated with perceived sleep disorders in methadone maintenance treatment (MMT) patients.

Insomnia, self-medication, and relapse to alcoholism.

Investigation of the frequencies of insomnia and its self-medication with alcohol in a group of alcoholic patients, as well as the relationship of these variables to alcoholic relapse found insomnia remained a robust predictor of relapse after application of logistic regression analysis to control for other variables.

Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms.

Patients on stable MMT have normal subjective daytime sleepiness but impaired daytime function that partially relates to depression, and changes in sleep architecture, presence of CSA, and blood methadone concentrations do not significantly affect subjective daytimeSleepiness and daytime function in these patients.

Sleep-disordered breathing and chronic opioid therapy.

The dose-response relation of sleep apnea to methadone and benzodiazepines calls for increased vigilance.

Sleep problems reported by patients entering opioid agonist treatment.

Characterization of Substance Abuse Patients Presenting for Treatment at a University Psychiatric Hospital in Cairo, Egypt

Opiates were the major drug problem for most of patients, representing 75% of cases, whereas barbiturates, stimulants, hallucinogens, and inhalants were rarely found to be the majorDrug problem for patients, and injection was a significant problem for heroin users that needs to be addressed in treatment programs.

The effect of opioids on sleep architecture.

Single doses of oral opioid medications can significantly affect sleep architecture in healthy adults, and observed reductions in slow-wave sleep following opioid administration may have important implications for the pathogenesis of opioid-use related fatigue.

Effects of chronic treatment with methadone and naltrexone on sleep in addicts

Compared with methadone and controls, the naltrexone (μ-opioid antagonist) group showed the shortest sleep latency and the longest total sleep time, indicating that μ-agonists and μ-antagonists have different effects on sleep.

Central sleep apnea in stable methadone maintenance treatment patients.

Thirty percent of stable MMT patients have CSA, a minority of which can be explained by blood methadone concentration, and other physiologic variables may also play a role in the pathogenesis of CSA in M MT patients, and further research is indicated.