Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington’s Disease Mice

@inproceedings{Lebreton2015SleepPA,
  title={Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington’s Disease Mice},
  author={Fanny Lebreton and Sebastien Cayzac and Susanna Pietropaolo and Yannick Jeantet and Yoon H Cho},
  booktitle={PloS one},
  year={2015}
}
In hereditary neurodegenerative Huntington's disease (HD), there exists a growing consideration that sleep and circadian dysregulations may be important symptoms. It is not known, however, whether sleep abnormalities contribute to other behavioral deficits in HD patients and mouse models. To determine the precise chronology for sleep physiology alterations and other sensory, motor, psychiatric and cognitive symptoms of HD, the same R6/1 HD transgenics and their wild-type littermates were… CONTINUE READING
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