Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex.

@article{Bellesi2017SleepLP,
  title={Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex.},
  author={Michele Bellesi and Luisa de Vivo and Mattia Chini and Francesca Gilli and Giulio Tononi and Chiara Cirelli},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2017},
  volume={37 21},
  pages={
          5263-5273
        }
}
We previously found that Mertk and its ligand Gas6, astrocytic genes involved in phagocytosis, are upregulated after acute sleep deprivation. These results suggested that astrocytes may engage in phagocytic activity during extended wake, but direct evidence was lacking. Studies in humans and rodents also found that sleep loss increases peripheral markers of inflammation, but whether these changes are associated with neuroinflammation and/or activation of microglia, the brain's resident innate… CONTINUE READING
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