Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability

  title={Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability},
  author={Masashi Tabuchi and Shahnaz Rahman Lone and Sha Liu and Qili Liu and Julia Xianzhi Zhang and Adam P. Spira and Mark N Wu},
  journal={Current Biology},
BACKGROUND Emerging data suggest an important relationship between sleep and Alzheimer's disease (AD), but how poor sleep promotes the development of AD remains unclear. RESULTS Here, using a Drosophila model of AD, we provide evidence suggesting that changes in neuronal excitability underlie the effects of sleep loss on AD pathogenesis. β-amyloid (Aβ) accumulation leads to reduced and fragmented sleep, while chronic sleep deprivation increases Aβ burden. Moreover, enhancing sleep reduces A… CONTINUE READING
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