Sleep Deprivation Potentiates Activation of Cardiovascular and Catecholamine Responses in Abstinent Alcoholics

@article{Irwin2005SleepDP,
  title={Sleep Deprivation Potentiates Activation of Cardiovascular and Catecholamine Responses in Abstinent Alcoholics},
  author={Michael R. Irwin and Michael G. Ziegler},
  journal={Hypertension},
  year={2005},
  volume={45},
  pages={252-257}
}
Alcohol dependence is associated with an increased incidence of hypertension and cardiac arrhythmias, but the triggering mechanisms are not known. Sleep loss, common in alcohol-dependent patients, causes an activation of the sympathetic nervous system. To determine whether sleep deprivation induces differential cardiovascular and sympathetic responses in alcohol dependence, we measured heart rate, blood pressure, and circulating sympathetic catecholamines in 36 abstinent alcohol-dependent men… 
View on Wolters Kluwer
ahajournals.org
50 Citations
Highly Influential Citations
1
Background Citations
23
Methods Citations
1
Results Citations
1

Figures from this paper

50 Citations

Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers
Association Between Nocturnal Vagal Tone and Sleep Depth, Sleep Quality, and Fatigue in Alcohol Dependence
TLDR
Alcohol dependence compromises vagal output measured before sleep onset, which correlates with loss of delta sleep and with morning reports of sleep impairments, and testing of interventions that target sympathovagal balance might identify new strategies for partial amelioration of the sleep disturbances and impairments in daytime functioning observed in persons with alcohol dependence.
One night of partial sleep deprivation affects biomarkers of cardiac damage, but not cardiovascular and lipid profiles, in young athletes
TLDR
Results show that PSDEN increases cardiac damage biomarkers significantly, even though they do not reach clinical significance, and thus, one night of PSD does not affect the physiological responses and biomarkers of LP in Taekwondo athletes.
Tumor Necrosis Factor Antagonism Normalizes Rapid Eye Movement Sleep in Alcohol Dependence
Sleep, sleep-disordered breathing and metabolic consequences
TLDR
The relative role of obesity and OSA in the pathogenesis of metabolic alterations is still unclear and is intensively studied in clinical and experimental models.
Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.
TLDR
The results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.
Polysomnographic measures of sleep in cocaine dependence and alcohol dependence: Implications for age‐related loss of slow wave, stage 3 sleep
TLDR
Cocaine and alcohol dependence appear to be associated with marked disturbances of sleep architecture, including increased rapid eye movement sleep and accelerated age‐related loss of slow wave, Stage 3 sleep.
Sleep deprivation, sleep apnea and cardiovascular diseases.
TLDR
There is convincing data regarding the associations between hypertension, arrhythmias, stroke, coronary heart disease, increased cardiovascular mortality and OSA, and whether treating sleep apnea enables the reversal of chronic cardiovascular and metabolic consequences of OSA remains to be studied in adequately designed studies.
Sex differences in cardiac sympathovagal balance and vagal tone during nocturnal sleep.
Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
TLDR
A molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus is explored, specifically examining the relationship between sleep duration and the immune and endocrine systems.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications.
TLDR
It is concluded that sleep onset is associated with changes in levels of circulating catecholamine and interleukin-2, and loss of sleep and disordered sleep with decreases in slow wave sleep may serve to elevate nocturnal catechlamine levels and contribute to cardiovascular disease.
Suppression of alcohol-induced hypertension by dexamethasone.
TLDR
Alcohol induces pressor effects by sympathetic activation that appear to be centrally mediated and it is possible that these alcohol-induced hemodynamic and sympathetic actions could participate in triggering cardiovascular events.
Influence of increased adrenergic activity and magnesium depletion on cardiac rhythm in alcohol withdrawal.
TLDR
Increased adrenergic activity, magnesium depletion, and hypokalaemia are often seen after heavy drinking, but in alcoholic men without clinical heart disease these changes were not accompanied by arrhythmias other than sinus tachycardia during detoxification in hospital.
Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
Cardiovascular responses to physical and psychological stress in female alcoholics with transitory hypertension after early abstinence.
TLDR
Although the pattern of cardiovascular dysregulation seems to be different in female alcoholics than in males, it is consistent with studies showing that cardiovascular effects in women are more severe than in men and emerge at a lower threshold level of chronic drinking.
Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study.
Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
TLDR
Sleep stage analyses indicated that the nocturnal increase in IL-6 occurred in association with stage 1-2 sleep and rapid eye movement sleep, but levels during slow wave sleep were not different from those while awake.
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Blood pressure dysregulation associated with alcohol withdrawal.
TLDR
The results suggest that transitory elevations in blood pressure observed during alcohol withdrawal may predict future BP abnormalities.
Hemodynamic alterations in alcohol-related transitory hypertension.
...
...