Sleep Deprivation Potentiates Activation of Cardiovascular and Catecholamine Responses in Abstinent Alcoholics
@article{Irwin2005SleepDP, title={Sleep Deprivation Potentiates Activation of Cardiovascular and Catecholamine Responses in Abstinent Alcoholics}, author={Michael R. Irwin and Michael G. Ziegler}, journal={Hypertension}, year={2005}, volume={45}, pages={252-257} }
Alcohol dependence is associated with an increased incidence of hypertension and cardiac arrhythmias, but the triggering mechanisms are not known. Sleep loss, common in alcohol-dependent patients, causes an activation of the sympathetic nervous system. To determine whether sleep deprivation induces differential cardiovascular and sympathetic responses in alcohol dependence, we measured heart rate, blood pressure, and circulating sympathetic catecholamines in 36 abstinent alcohol-dependent men…
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References
SHOWING 1-10 OF 52 REFERENCES
Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 1999
It is concluded that sleep onset is associated with changes in levels of circulating catecholamine and interleukin-2, and loss of sleep and disordered sleep with decreases in slow wave sleep may serve to elevate nocturnal catechlamine levels and contribute to cardiovascular disease.
Suppression of alcohol-induced hypertension by dexamethasone.
- MedicineThe New England journal of medicine
- 1995
Alcohol induces pressor effects by sympathetic activation that appear to be centrally mediated and it is possible that these alcohol-induced hemodynamic and sympathetic actions could participate in triggering cardiovascular events.
Influence of increased adrenergic activity and magnesium depletion on cardiac rhythm in alcohol withdrawal.
- MedicineBritish heart journal
- 1994
Increased adrenergic activity, magnesium depletion, and hypokalaemia are often seen after heavy drinking, but in alcoholic men without clinical heart disease these changes were not accompanied by arrhythmias other than sinus tachycardia during detoxification in hospital.
Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
- MedicineBrain, Behavior, and Immunity
- 2004
Cardiovascular responses to physical and psychological stress in female alcoholics with transitory hypertension after early abstinence.
- MedicineAlcoholism, clinical and experimental research
- 2003
Although the pattern of cardiovascular dysregulation seems to be different in female alcoholics than in males, it is consistent with studies showing that cardiovascular effects in women are more severe than in men and emerge at a lower threshold level of chronic drinking.
Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study.
- Medicine, BiologyAmerican journal of hypertension
- 1999
Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 2000
Sleep stage analyses indicated that the nocturnal increase in IL-6 occurred in association with stage 1-2 sleep and rapid eye movement sleep, but levels during slow wave sleep were not different from those while awake.
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
- Psychology, BiologyBrain, Behavior, and Immunity
- 2003
Blood pressure dysregulation associated with alcohol withdrawal.
- MedicineAlcoholism, clinical and experimental research
- 1991
The results suggest that transitory elevations in blood pressure observed during alcohol withdrawal may predict future BP abnormalities.