Sleep–wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry

@article{Zhong2011SleepwakeDI,
  title={Sleep–wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry},
  author={George Zhong and Sharon L. Naismith and Naomi L. Rogers and Simon J. G. Lewis},
  journal={Journal of the Neurological Sciences},
  year={2011},
  volume={307},
  pages={9-14}
}

Figures from this paper

Alterations of the circadian system in Parkinson's disease patients
  • K. Fifel
  • Biology, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2017
TLDR
The relative causal contribution to health impairments in Parkinson's Disease patients of dysfunctions in the different components of the neural network governing circadian rhythms is dissected.
Pathology of behavior in PD: What is known and what is not?
Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases
TLDR
Effective treatments for the sleep disorders associated with neurodegenerative diseases are urgently needed, but current data are insufficient to establish melatonin as such a treatment.
Assessing the role of nocturnal core body temperature dysregulation as a biomarker of neurodegeneration
TLDR
Thermoregulatory dysfunction is implicate as a potential early biomarker for development of rapid eye movement sleep behaviour disorder‐associated neurodegeneration, and subpopulations with differing pathological underpinnings might exist in Parkinson’s disease.
Sleep disruption and cognitive dysfunction in Parkinson’s disease: does sleep disturbance exacerbate cognitive symptoms?
TLDR
This study tested the hypothesis that a multidimensional measurement model would best fit the Parkinson’s Disease Sleep Scale-Revised (PDSS-R), and demonstrated that factors were differentially associated with age, personality and mood.
Sleep quality in healthy older people: relationship with ¹H magnetic resonance spectroscopy markers of glial and neuronal integrity.
TLDR
Results indicate that in healthy older people, subjective sleep disturbance may be associated with glial alterations in the hippocampus, and future research is now needed to examine these associations with respect to objective sleep measures and overnight memory consolidation.
Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework.
TLDR
The history, clinical phenomenology and assessment of cognitive fluctuations in the Lewy body dementias are examined, and the key neuropsychological, neurophysiological and neuroimaging correlates of Cognitive fluctuations are described and integrated into a novel testable heuristic framework from which new insights may be gained.
OP-BRAI190318 1..16
TLDR
The history, clinical phenomenology and assessment of cognitive fluctuations in the Lewy body dementias are examined, and the key neuropsychological, neurophysiological and neuroimaging correlates of Cognitive fluctuations are described and integrated into a novel testable heuristic framework from which new insights may be gained.
The Relationship between Thermoregulation and REM Sleep Behaviour Disorder in Parkinson’s Disease
TLDR
The findings suggest that the brainstem pathology associated with disruption of thermoregulation in Parkinson’s disease may also contribute to rapid eye movement sleep behavioural disorder.
...
...

References

SHOWING 1-10 OF 83 REFERENCES
Neurobiology of sleep disturbances in neurodegenerative disorders.
TLDR
Since sleep disruption may occur early in the course of neurodegeneration, sleep disturbance may serve as groundwork to study the efficacy of neuroprotective agents to prevent or delay the development of a full-blown neurodegenersative disorder.
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.
TLDR
The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented.
REM sleep behavior disorder and the risk of developing Parkinson disease or dementia
TLDR
Whether all patients with idiopathic RBD eventually develop Parkinson disease (PD) or dementia (or have alpha-synuclein pathology in brainstem nuclei such as the subcerular area at postmortem) remains uncertain, but the question is of practical importance.
Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
TLDR
The risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.
Does Alzheimer's disease begin in the brainstem?
TLDR
It is speculated that cumulative oxidative damage may be the main cause of DRN alterations, as the age is the main risk factor for sporadic AD.
Sleep Well, Think Well: Sleep-Wake Disturbance in Mild Cognitive Impairment
TLDR
Preliminary data suggests that sleep-wake disturbance in nonamnestic forms of MCI is related to cognitive functioning and may be indicative of shared neurobiological underpinnings.
Hypocretin (orexin) cell loss in Parkinson’s disease
TLDR
It is found that Parkinson’s disease is characterized by a massive loss of Hcrt neurons, which may be a cause of the narcolepsy-like symptoms of PD and may be ameliorated by treatments aimed at reversing the HCRt deficit.
Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia.
TLDR
Excessive daytime sleepiness is more frequent in Parkinson's disease patients with dementia than Parkinson’s disease patients without dementia, but lumbar cerebrospinal fluid hypocretin-1 levels are normal and unrelated to severity of sleepiness or the cognitive status.
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
To appreciate the neural underpinnings of sleep, it is important to view this universal mammalian behaviour at multiple levels of its biological organization. Molecularly, the circadian rhythm of
Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia.
TLDR
Evidence is provided that both vasopressin and neurotensin neurons are lost in Alzheimer disease, and that the astrocyte/neuron ratio is a reliable indicator of disease-related pathology within the SCN.
...
...