Sleep–wake behavior and responses of interleukin-6-deficient mice to sleep deprivation

  title={Sleep–wake behavior and responses of interleukin-6-deficient mice to sleep deprivation},
  author={Jonathan D Morrow and Mark R. Opp},
  journal={Brain, Behavior, and Immunity},
Interleukin (IL)-1 and tumor necrosis factor (TNF) are involved in the regulation of non-rapid eye movements sleep (NREMS). Accumulating evidence suggests IL-6 modulates sleep under some pathophysiologic conditions. We used mice lacking a functional IL-6 gene to investigate further a potential role for IL-6 in the regulation of sleep. IL-6 knockout mice (B6.129S6-Il6tm1Kopf; n=10) and C57BL/6J mice (n=10) were purchased from the Jackson Laboratory (Bar Harbor, ME). Twenty-four-hour baseline… CONTINUE READING


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