Sleep, circadian rhythms, and schizophrenia: where we are and where we need to go

@article{Cosgrave2018SleepCR,
  title={Sleep, circadian rhythms, and schizophrenia: where we are and where we need to go},
  author={Jan Cosgrave and Katharina Wulff and Philip R. Gehrman},
  journal={Current Opinion in Psychiatry},
  year={2018},
  volume={31},
  pages={176–182}
}
Purpose of review The review is designed to give an overview of the latest developments in research exploring the relationship between sleep and psychosis, with particular attention paid to the evidence for a causal relationship between the two. Recent findings The most interesting avenues currently in pursuit are focused upon sleep spindle deficits which may hallmark an endophenotype; explorations of the continuum of psychotic experiences, and experimental manipulations to explore the evidence… 
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References

SHOWING 1-10 OF 54 REFERENCES
Disrupting Sleep: The Effects of Sleep Loss on Psychotic Experiences Tested in an Experimental Study With Mediation Analysis
TLDR
The overall conclusion is that insomnia has a causal role in the occurrence of certain psychotic experiences, and that a key route is via negative affect.
Sleep Dysfunctions in Schizophrenia: A Practical Review
TLDR
A better understanding of sleep problems in schizophrenia will lead to increased treatment options, and a more positive clinical outcome, as well as help clinicians make more informed decisions about integrated treatment plans.
Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades
TLDR
Sleep deprivation represents a promising but possibly unspecific experimental model that may be helpful to further improve the understanding of the underlying mechanisms in the pathophysiology of psychosis and aid the development of antipsychotic and pro-cognitive drugs.
Do Sleep Disturbances and Psychotic-Like Experiences in Adolescence Share Genetic and Environmental Influences?
TLDR
The association between PLEs with sleep disturbances in adolescence is partly due to genetic and environmental influences that are common to them both, and the known neurobiology of sleep disturbance may provide clues regarding the causes of PSEs in adolescence.
Sleep Deprivation Disrupts Prepulse Inhibition and Induces Psychosis-Like Symptoms in Healthy Humans
TLDR
It is concluded that SD, in combination with the PPI biomarker, might be a promising translational surrogate model for psychosis as this method represents a possibility to partially and reversibly mimic the pathogenesis of psychotic states.
Sleep and circadian rhythm disruption in social jetlag and mental illness.
Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings
TLDR
Sleep spindles are wax and waning brain oscillations at a frequency range of 11–16 Hz, lasting 0.5–2 s, that define non-rapid eye movement sleep stage 2 and remain the only condition with a typical late adolescence to young adulthood onset in which impaired spindling has been consistently reported.
...
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