Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice

@article{Peters2007Slc11a1N,
  title={Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice},
  author={Luciana Carla Peters and Jos{\'e} Ricardo Jensen and Andrea Borrego and Wafa Hanna Koury Cabrera and Noel T Baker and Nancy Starobinas and Orlando Garcia Ribeiro and Olga C{\'e}lia Martinez Iba{\~n}ez and Marcelo De Franco},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={51-56}
}
Mice selected for the maximum acute inflammatory reaction (AIRmax) are highly susceptible to pristane-induced arthritis (PIA), whereas mice selected for the minimum response (AIRmin) are resistant. These lines show distinct patterns of leukocyte infiltration and R and S allele frequency disequilibrium of the solute carrier family 11a member 1 (Slc11a1) gene. In order to study the interactions of the Slc11a1 R and S alleles with the inflammation modulating Quantitative Trait Loci (QTL) during… CONTINUE READING

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