Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.

@article{Fritsche2012Slc11a1I,
  title={Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.},
  author={Gernot Fritsche and Manfred Nairz and Stephen James Libby and Ferric C Fang and Guenter Weiss},
  journal={Journal of leukocyte biology},
  year={2012},
  volume={92 2},
  pages={353-9}
}
The expression of the cation transporter Nramp1 (Slc11a1) in late phagolysosomes confers resistance to infection with several intracellular pathogens, such as Salmonella enterica, in mice. The antimicrobial actions of Nramp1 are attributable, in part, to modulation of macrophage immune function and cellular iron metabolism--the latter affecting the availability of the essential nutrient iron for intraphagosomal bacteria. Here, we provide novel evidence that Nramp1 functionality increases the… CONTINUE READING

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