Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells.

@article{Warkiani2014SlantedSM,
  title={Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells.},
  author={Majid Ebrahimi Warkiani and Guofeng Guan and Khoo Bee Luan and Wong Cheng Lee and Ali Asgar S. Bhagat and Parthiv Kant Chaudhuri and Daniel Shao-Weng Tan and Wan Teck Lim and Soo Chin Lee and Peter C. Y. Chen and Chwee Teck Lim and Jongyoon Han},
  journal={Lab on a chip},
  year={2014},
  volume={14 1},
  pages={128-37}
}
The enumeration and characterization of circulating tumor cells (CTCs), found in the peripheral blood of cancer patients, provide a potentially accessible source for cancer diagnosis and prognosis. This work reports on a novel spiral microfluidic device with a trapezoidal cross-section for ultra-fast, label-free enrichment of CTCs from clinically relevant blood volumes. The technique utilizes the inherent Dean vortex flows present in curvilinear microchannels under continuous flow, along with… CONTINUE READING

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