Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function.

@article{Aktan2010SlamHM,
  title={Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function.},
  author={Idil Aktan and Alan Chant and Zachary D. Borg and David E Damby and Paige C. Leenstra and Graham W. J. Lilley and Joseph W. Petty and Benjamin T Suratt and Cory Teuscher and Edward K. Wakeland and Matthew E Poynter and Jonathan E Boyson},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={
          144-56
        }
}
CD1d-restricted NKT cells make up an innate-like T cell subset that plays a role in amplifying the response of innate immune leukocytes to TLR ligands. The Slam locus contains genes that have been implicated in innate and adaptive immune responses. In this study, we demonstrate that divergent Slam locus haplotypes modulate the response of macrophages to the TLR4 ligand LPS through their control of NKT cell number and function. In response to LPS challenge in vivo, macrophage TNF production in… CONTINUE READING
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