Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics.

  title={Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics.},
  author={Derek T. Warren and Paul D. Andrews and Campbell W Gourlay and Kathryn R Ayscough},
  journal={Journal of cell science},
  volume={115 Pt 8},
Sla1p is a protein required for cortical actin patch structure and organisation in budding yeast. Here we use a combination of immunofluorescence microscopy and biochemical approaches to demonstrate interactions of Sla1p both with proteins regulating actin dynamics and with proteins required for endocytosis. Using Sla1p-binding studies we reveal association of Sla1p with two proteins known to be important for activation of the Arp2/3 complex in yeast, Abp1p and the yeast WASP homologue Las17p… CONTINUE READING
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