Skp2 regulates G2/M progression in a p53-dependent manner.

@article{Hu2008Skp2RG,
  title={Skp2 regulates G2/M progression in a p53-dependent manner.},
  author={Rong Hu and Andrew E. Aplin},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 11},
  pages={
          4602-10
        }
}
Targeted proteasomal degradation mediated by E3 ubiquitin ligases controls cell cycle progression, and alterations in their activities likely contribute to malignant cell proliferation. S phase kinase-associated protein 2 (Skp2) is the F-box component of an E3 ubiquitin ligase complex that targets p27(Kip1) and cyclin E1 to the proteasome. In human melanoma, Skp2 is highly expressed, regulated by mutant B-RAF, and required for cell growth. We show that Skp2 depletion in melanoma cells resulted… CONTINUE READING

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