Skp2 is oncogenic and overexpressed in human cancers.

  title={Skp2 is oncogenic and overexpressed in human cancers.},
  author={Matthias Gstaiger and Richard D. Jordan and Michael S Lim and Charles Catzavelos and Juergen Mestan and Joyce Slingerland and Wilhelm Krek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 9},
Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin-protein ligase complexes that has been implicated in the ubiquitin-mediated degradation of several key regulators of mammalian G(1) progression, including the cyclin-dependent kinase inhibitor p27, a dosage-dependent tumor suppressor protein. In this study, we examined Skp2 and p27 protein expression by immunohistochemistry in normal oral epithelium and in different stages of malignant oral cancer… CONTINUE READING