Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker.

@article{Zhu2004Skp2GC,
  title={Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker.},
  author={Chang Qi Zhu and Fiona Blackhall and Melania Pintilie and Pratibha Iyengar and Ni Liu and James Ho and Taylor Chomiak and Davina Lau and Timothy R Winton and Frances A. Shepherd and Ming-Sound Tsao},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 6},
  pages={1984-91}
}
PURPOSE Skp2 plays a critical role in cell cycle progression, especially at the G(1)-S transition, putatively through its control of several cell cycle regulator proteins. The Skp2 gene is located on a region of chromosome 5p that is commonly overrepresented in lung cancer. The present study aimed to evaluate Skp2 abnormalities and their prognostic value in non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN In total 16 NSCLC cell lines and 163 primary tumors were included in studies to… CONTINUE READING

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