Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.

@article{Old2010Skp2DM,
  title={Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.},
  author={Jennifer B Old and Susanne Kratzat and Alexander Hoellein and Steffi Graf and Jonas Nilsson and Lisa Nilsson and Keiichi I Nakayama and Christian Peschel and John L. Cleveland and Ulrich B Keller},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 3},
  pages={353-62}
}
The universal cyclin-dependent kinase inhibitor p27(Kip1) functions as a tumor suppressor, and reduced levels of p27(Kip1) connote poor prognosis in several human malignancies. p27(Kip1) levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the E3 ubiquitin ligase SCF(Skp2) complex following its phosphorylation by the cyclin E-cyclin-dependent kinase 2 complex. Binding of phospho-p27(Kip1) is directed by the Skp2 F-box protein, and… CONTINUE READING
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An integrated database of genes responsive to the Myc oncogenic Mol Cancer Res

  • KI Zeller, AG Jegga, BJ Aronow, KA O'Donnell, CV. Dang
  • Old et al
  • 2010
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