Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.

@article{Taylor2015SkipRM,
  title={Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.},
  author={Keenan C. Taylor and Massimo Buvoli and Elif Nihal Korkmaz and Ada Buvoli and Yuqing Zheng and Nathan T Heinze and Qiang Cui and L. A. Leinwand and Ivan Rayment},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 29},
  pages={E3806-15}
}
The rod of sarcomeric myosins directs thick filament assembly and is characterized by the insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats. We report here that the regions surrounding the first three skip residues share high structural similarity despite their low sequence homology. Near each of these skip residues, the coiled-coil transitions to a nonclose-packed structure inducing local relaxation of the superhelical pitch. Moreover, molecular… CONTINUE READING

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AMBER 12 (Univ of California, San Francisco, CA)

  • DA Case
  • Available at ambermd.org/doc12/Amber12.pdf…
  • 2012

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