Skin wounds and severed nerves heal normally in mice lacking tenascin-C.

  title={Skin wounds and severed nerves heal normally in mice lacking tenascin-C.},
  author={Erik Forsberg and Emmet Hirsch and Luise Fr{\"o}hlich and Matthias Meyer and Peter Ekblom and Attila Aszodi and Stefan Werner and Reinhard F{\"a}ssler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 13},
A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments. However, these results contrast sharply with the lack of any apparent phenotype in mice with a genetic deletion of tenascin-C. A possible explanation for the lack of phenotype would be expression of some altered but functional tenascin-C in the mutant. We report the generation of an independent tenascin-C null mouse and conclude that the original tenascin-C… CONTINUE READING
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