Skin susceptibility of atopic individuals

@article{Lffler1999SkinSO,
  title={Skin susceptibility of atopic individuals},
  author={Harald L{\"o}ffler and Isaak Effendy},
  journal={Contact Dermatitis},
  year={1999},
  volume={40}
}
The relevance of the irritant skin reaction of individuals with an atopic history (atopic dermatitis, rhinoconjunctivitis or atopic asthma) to sodium lauryl sulfate (SLS), a widely used irritant, is still controversial. The aim of this study was to evaluate transepidermal water loss (TEWL) as an indicator of stratum corneum integrity, before and after SLS patch testing, in various groups of atopic individuals with and without atopic dermatitits. 95 volunteers were divided into 4 groups: (1… 

Cutaneous response to irritants

There is no proof that the healthy skin of active atopic subjects is the most susceptible to the irritating effects of the tested substances, and the results of this study seem to indicate that the substances of the first panel have a chemical structure that makes them quite safe in real‐life conditions.

Contact dermatitis in atopic individuals

  • R. Spiewak
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2012
The interplay between atopy and diseases from the spectrum of dermatitis and eczema is not fully understood; nevertheless, their coexistence and overlapping are not rare.

Allergic Contact Dermatitis and Atopic Eczema

Clinical findings reported to date are outlined and the basic mechanism of allergic contact dermatitis (ACD) in relation to relevant pathogenetic characteristics of AE is reviewed, possibly interfering with the pathogenesis of ACD.

OPINION Contact dermatitis in atopic individuals

It seems at present that atopy does not, whereas atopic eczema does constitute a risk factor for irritant contact dermatitis, while there is insufficient data to state upon the relationship between atopy and allergicContact dermatitis.

Patch‐test reaction patterns in patients with a predisposition to atopic dermatitis

Compared to the matched controls, patients with a predisposition to atopic dermatitis tended to have more doubtful and irritant reactions on day 1 and as a new observation, it turned out that they had less reactions of crescendo pattern and more strong reaction on day 3.

Clinical Aspects of Irritant Contact Dermatitis

Therapy and prevention require identification of irritants and reduction of skin contact by gloves or technical measures, and sensitization to environmental allergens does exist and is frequently associated with previous atopic dermatitis.
...

References

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The skin response to sodium lauryl sulphate was found to be statistically significantly increased in atopic patients compared with controls when evaluated by visual scoring and by increase in skin thickness, but not in transepidermal water loss, blood flow or skin colour.

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Assessing the susceptibility of clinically normal skin to a standard irritant trauma under varying physiological and patophysiological conditions may be useful for the identification of high-risk subjects for development of irritant contact dermatitis, and may help to prevent the formation of the disease.