Skin susceptibility of atopic individuals

@article{Lffler1999SkinSO,
  title={Skin susceptibility of atopic individuals},
  author={Harald L{\"o}ffler and Isaak Effendy},
  journal={Contact Dermatitis},
  year={1999},
  volume={40}
}
The relevance of the irritant skin reaction of individuals with an atopic history (atopic dermatitis, rhinoconjunctivitis or atopic asthma) to sodium lauryl sulfate (SLS), a widely used irritant, is still controversial. The aim of this study was to evaluate transepidermal water loss (TEWL) as an indicator of stratum corneum integrity, before and after SLS patch testing, in various groups of atopic individuals with and without atopic dermatitits. 95 volunteers were divided into 4 groups: (1… 
Cutaneous response to irritants
TLDR
There is no proof that the healthy skin of active atopic subjects is the most susceptible to the irritating effects of the tested substances, and the results of this study seem to indicate that the substances of the first panel have a chemical structure that makes them quite safe in real‐life conditions.
Contact dermatitis in atopic individuals
  • R. Spiewak
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2012
TLDR
The interplay between atopy and diseases from the spectrum of dermatitis and eczema is not fully understood; nevertheless, their coexistence and overlapping are not rare.
Allergic Contact Dermatitis and Atopic Eczema
TLDR
Clinical findings reported to date are outlined and the basic mechanism of allergic contact dermatitis (ACD) in relation to relevant pathogenetic characteristics of AE is reviewed, possibly interfering with the pathogenesis of ACD.
OPINION Contact dermatitis in atopic individuals
TLDR
It seems at present that atopy does not, whereas atopic eczema does constitute a risk factor for irritant contact dermatitis, while there is insufficient data to state upon the relationship between atopy and allergicContact dermatitis.
Patch‐test reaction patterns in patients with a predisposition to atopic dermatitis
TLDR
Compared to the matched controls, patients with a predisposition to atopic dermatitis tended to have more doubtful and irritant reactions on day 1 and as a new observation, it turned out that they had less reactions of crescendo pattern and more strong reaction on day 3.
Clinical Aspects of Irritant Contact Dermatitis
TLDR
Therapy and prevention require identification of irritants and reduction of skin contact by gloves or technical measures, and sensitization to environmental allergens does exist and is frequently associated with previous atopic dermatitis.
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References

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TLDR
Clinical dry skin was more susceptible than normal skin, though no difference was noted in the pre‐exposure barrier function, and the increased susceptibility to irritants in those with a past history of AD was probably due to impaired barrier function.
Allergic and irritant patch test reactions and atopic disease
TLDR
It is concluded that atopics are at least as likely to have ACD as are non‐u topics and the frequency of irritant reactions correlates with both greater numbers of ACD responses and with presence of atopy.
Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis.
TLDR
Significantly greater frequency of response to sodium lauryl sulfate in both AD groups and also in patients with allergic rhinitis with no dermatitis was seen, and it is hypothesized that abnormal intrinsic hyperreactivity in inflammatory cells, rather than in skin cells, in atopic individuals predisposes to a lowered threshold of irritant responsiveness.
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TLDR
The conclusion is that atopics and non‐atopics will give similar results in a predictive human test for acute skin irritation, and the pattern of response obtained from short duration exposure should be predictive of that following longer durations of (single) exposure.
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TLDR
The epidermal barrier function in AE patients is altered only in positive APT reactions, in contrast to positive patch test reactions to contact allergens, which means further allergens can more easily penetrate the skin, inducing a vicious circle and perpetuating the eczematous lesions.
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TLDR
The results of the linear regression analysis demonstrate that skin atopy is not associated with increased skin irritability, as assessed by the irritability testing methods presented.
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TLDR
The skin response to sodium lauryl sulphate was found to be statistically significantly increased in atopic patients compared with controls when evaluated by visual scoring and by increase in skin thickness, but not in transepidermal water loss, blood flow or skin colour.
Irritant susceptibility and weal and flare reactions to bioactive agents in atopic dermatitis. I. Influence of disease severity
TLDR
It is proposed that epicutaneous irritant susceptibility and reactivity to intracutaneous bioactive agents may be useful indicators of non‐specific skin reactivity in AD.
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TLDR
Assessing the susceptibility of clinically normal skin to a standard irritant trauma under varying physiological and patophysiological conditions may be useful for the identification of high-risk subjects for development of irritant contact dermatitis, and may help to prevent the formation of the disease.
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