Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography.

@article{Greaves2015SkinSR,
  title={Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography.},
  author={Nicholas Stuart Greaves and Syed A. Iqbal and Tom Hodgkinson and Julie A Morris and Brian Benatar and Teresa Alonso-Rasgado and Mohamed S Baguneid and Ardeshir Bayat},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2015},
  volume={23 4},
  pages={483-94}
}
Skin substitutes are heterogeneous biomaterials designed to accelerate wound healing through provision of replacement extracellular matrix. Despite growing evidence for their use in chronic wounds, the role of skin substitutes in acute wound management and their influence on fibrogenesis remains unclear. Skin substitute characteristics including biocompatibility, porosity, and elasticity strongly influence cellular behavior during wound healing. Thus, we hypothesize that structural and… CONTINUE READING
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