Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18.

@article{Yamanaka2000SkinspecificCM,
  title={Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18.},
  author={Kei-ichi Yamanaka and Masato Tanaka and Hiroko Tsutsui and Thomas S Kupper and Ken-ichi Asahi and Hitoshi Okamura and Kenji Nakanishi and Motoharu Suzuki and Nobuhiko Kayagaki and Roy Black and Douglas K. Miller and Kosuke Nakashima and Motomu Shimizu and Hirotake Mizutani},
  journal={Journal of immunology},
  year={2000},
  volume={165 2},
  pages={997-1003}
}
To study the pathophysiological roles of overexpressed caspase-1 (CASP1), originally designated as IL-1 beta-converting enzyme, we generated transgenic mice in which human CASP1 is overexpressed in their keratinocytes. The transgenic mice spontaneously developed recalcitrant dermatitis and skin ulcers, characterized by the presence of massive keratinocyte apoptosis. The skin of the mice contained the active form of human CASP1 and expressed mRNA for caspase-activated DNase, an effector… CONTINUE READING

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