Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models.

@article{Heise2006SkinRC,
  title={Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models.},
  author={Ruth Heise and J. E. Vander Mey and Mark M Neis and Yvonne Marquardt and Sylvia Joussen and Hagen Ott and Tonio Wiederholt and Peter Kurschat and Mosaad Megahed and David R. Bickers and Hans Friedrich Merk and Jens M Baron},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 11},
  pages={2473-80}
}
Cellular levels of all-trans retinoic acid (RA) are meticulously regulated utilizing an array of systems to balance uptake, biosynthesis, catabolism, and efflux transport. Metabolic transformation of all-trans RA to 4-hydroxylated RA appears to be primarily catalyzed by the cytochrome P450 (CYP) 26AI. Analysis of monolayer cultures of normal human epidermal keratinocytes (NHEKs) and dermal fibroblasts by quantitative real-time PCR and reverse transcription-PCR revealed no basal levels of… CONTINUE READING

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