Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.

@article{Igyrt2011SkinresidentMD,
  title={Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.},
  author={Botond Z. Igy{\'a}rt{\'o} and Krystal M Haley and Daniela Ortner and Aleh A. Bobr and Maryam Gerami-Nejad and Brian T. Edelson and Sandra Zurawski and Bernard Malissen and Gerard Zurawski and Judith Berman and Daniel H Kaplan},
  journal={Immunity},
  year={2011},
  volume={35 2},
  pages={260-72}
}
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the… CONTINUE READING