Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion

  title={Skin permeation mechanism and bioavailability enhancement of celecoxib from transdermally applied nanoemulsion},
  author={Faiyaz Shakeel and Sanjula Baboota and Alka Ahuja and Javed Ali and Sheikh Shafiq},
  journal={Journal of Nanobiotechnology},
  pages={8 - 8}
BACKGROUND Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was to assess the skin permeation mechanism and bioavailability of celecoxib by transdermally applied nanoemulsion… CONTINUE READING


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