Skin permeation enhancement of tegafur by ethanol/panasate 800 or ethanol/water binary vehicle and combined effect of fatty acids and fatty alcohols.

@article{Lee1993SkinPE,
  title={Skin permeation enhancement of tegafur by ethanol/panasate 800 or ethanol/water binary vehicle and combined effect of fatty acids and fatty alcohols.},
  author={C. Lee and T. Uchida and E. Noguchi and N. Kim and S. Goto},
  journal={Journal of pharmaceutical sciences},
  year={1993},
  volume={82 11},
  pages={
          1155-9
        }
}
  • C. Lee, T. Uchida, +2 authors S. Goto
  • Published 1993
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • The effects of vehicle and enhancer on the skin permeation of tegafur across excised hairless mouse skin were investigated. Ethanol, water, panasate 800 (tricaprylin), and their mixtures were used as vehicles, and then a series of fatty acids or fatty alcohols was employed as representative enhancers. The skin permeability of tegafur was dramatically increased by the combination of ethanol and panasate 800, whereas the combination of ethanol and water resulted in only a little increase. The… CONTINUE READING
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