Skin penetration and distribution of polymeric nanoparticles.

@article{lvarezRomn2004SkinPA,
  title={Skin penetration and distribution of polymeric nanoparticles.},
  author={Roc{\'i}o {\'A}lvarez-Rom{\'a}n and Aarti Naik and Yogeshvar N. Kalia and Richard H Guy and Hafedh Fessi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={99 1},
  pages={
          53-62
        }
}
  • R. Álvarez-Román, A. Naik, +2 authors H. Fessi
  • Published 14 September 2004
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
Encapsulation using nanoparticulate systems is an increasingly implemented strategy in drug targeting and delivery. Such systems have also been proposed for topical administration to enhance percutaneous transport into and across the skin barrier. However, the mechanism by which such particulate formulations facilitate skin transport remains ambiguous. In this study, confocal laser scanning microscopy (CLSM) was used to visualize the distribution of non-biodegradable, fluorescent, polystyrene… Expand
Nanoparticles and microparticles for skin drug delivery.
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Investigation of biodegradable poly-lactic acid (PLA) particles loaded with fluorescent dyes as carriers for transepidermal drug delivery suggests that particles based on PLA polymers may be ideal carriers for hair follicle and sebaceous gland targeting. Expand
Microneedle mediated delivery of nanoparticles into human skin.
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Examples of triggered drug release are presented, which can be designed as transport systems delivering drugs efficiently into the hair follicles in the vicinity of specific target structures and exert their effects on the target cells. Expand
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Results demonstrate objectively and semi-quantitatively that nanoparticles contacting intact, and even partially damaged, skin cannot penetrate beyond the superficial layers of the barrier, and are highly unlikely, therefore, to reach the viable cells of the epidermis or beyond. Expand
Characterization and evaluation of novel nano/meso-particulate formulations for application to the skin
The use of nano/meso-particles (NP/MP) as constituent of topical formulations of drug and cosmetics has been a topic of considerable interest for the past 20 years. However, the transport mechanismExpand
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The altered distribution of NR when delivered via nanoparticles was due, at least in part, to its altered thermodynamic activity and, as a result, an increase in its partition coefficient into the SC. Expand
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The view that follicular drug targeting using 5-µm polymeric microspheres may represent a promising therapeutic approach for the treatment of pathologies associated with pilosebaceous units is supported. Expand
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Enhanced retinol palmitate uptake should derive from specific SLN effects and is not due to non-specific occlusive properties, as Transepidermal water loss (TEWL) and the influence of drug free SLN on retinyl palmitates uptake exclude pronounced Occlusive effects. Expand
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Polysorbate‐80 coating enhances uptake of polybutylcyanoacrylate (PBCA)‐nanoparticles by human and bovine primary brain capillary endothelial cells
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Cultured microvessel brain endothelial cells of human and bovine origin were used as an in vitro model for the BBB and it is demonstrated that the nanoparticles are taken up by cells and that this uptake occurs via an endocytotic mechanism. Expand
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  • R. Álvarez-Román, G. Barre, R. Guy, H. Fessi
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2001
TLDR
The influence of polysorbate 85 and poloxamer 188 as stabilizing agents, the OMC loading capacity and the photoprotective potential of the formulations, and in vitro release of OMC-nanocapsules provided partial protection against UV-induced erythema, in a manner significantly better than a conventional gel. Expand
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All the liposomal formulations tested were far more effective than the emulsion formulation in depositing CSA into the skin, and the opposite effect was observed for human cadaver skin. Expand
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