Skin penetration and decontamination efficacy following human skin exposure to fentanyl.

  title={Skin penetration and decontamination efficacy following human skin exposure to fentanyl.},
  author={Lina Thors and Linda {\"O}berg and Emma Forsberg and Elisabeth Wigenstam and Andr{\'e}as Larsson and Anders Bucht},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  • L. Thors, Linda Öberg, A. Bucht
  • Published 12 June 2020
  • Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
Efficacy of water-based skin decontamination of occupational chemicals using in vitro human skin models: a systematic review
Varying study methodologies hinder the ability to compare data and determine when water alone or soap and water are best used, so international harmonized efficacy protocol might enhance decontamination understanding and enable a more customized approach to decontaminating clinical practice and research.
Percutaneous absorption of Carfentanil in vitro.


Dermal penetration of fentanyl: inter- and intraindividual variations.
The interindividual variation in dermal penetration of fentanyl was extensive, with maximal fluxes ranging from 21-105 ng/cm2/hr following application of an infinite dose of fentanyl to the donor chamber and use of transdermal drug delivery systems (patches) reduced the inter-individual variation.
Transdermal delivery of narcotic analgesics: comparative metabolism and permeability of human cadaver skin and hairless mouse skin.
It appears that these drugs pass through in intact form, and no measurable glucuronidation of morphine took place in human skin or hairless mouse skin, suggesting a low monooxygenase enzyme presence in skin.
Reactive skin decontamination lotion (RSDL) for the decontamination of chemical warfare agent (CWA) dermal exposure.
Evidence of R SDL's superior performance against vesicant and organophosphorus chemical warfare agents compared to water, bleach, and dry sorbents, suggests that RSDL may have a role in mass human exposure chemical decontamination in both the military and civilian arenas.
Clinical Pharmacokinetics of Transdermal Opioids
In cancer pain, TTS fentanyl offers an interesting alternative to oral morphine, and its effectiveness and tolerability in this indication has been demonstrated by a number of trials, while its usefulness in chronic pain of nonmalignant origin remains to be confirmed in controlled trials.
In vitro dermal absorption of carfentanil.
In vitro human skin penetration model for organophosphorus compounds with different physicochemical properties.