Skin morphology in porphyria cutanea tarda does not improve despite clinical remission.

@article{Timonen1991SkinMI,
  title={Skin morphology in porphyria cutanea tarda does not improve despite clinical remission.},
  author={Kaisa Timonen and Kaisa Niemi and Pertti Mustajoki},
  journal={Clinical and experimental dermatology},
  year={1991},
  volume={16 5},
  pages={355-8}
}
Five patients with porphyria cutanea tarda (PCT) were treated with a prolonged, low-dose chloroquine regimen (250 mg twice weekly). Their skin symptoms disappeared, and the abnormal urinary porphyrin excretion normalized during treatment periods ranging from 6 to 17 (mean 11.8) months. The morphology of the skin was studied by light and electron microscopy methods before treatment, at the onset of remission, and 6-12 months later. In samples taken during remission, the PAS-positive thickening… CONTINUE READING