Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes

@article{Wang2017SkinMP,
  title={Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes},
  author={Zhenping Wang and Nicholas L Mascarenhas and Lars Eckmann and Yukiko Miyamoto and Xiaojun Sun and Toshiaki Kawakami and Anna Di Nardo},
  journal={The Journal of Allergy and Clinical Immunology},
  year={2017},
  volume={139},
  pages={1205–1216.e6}
}
Background: Mast cell (MC) progenitors leave the bone marrow, enter the circulation, and settle in the skin and other tissues. Their maturation in tissues is influenced by the surrounding microenvironment. Objective: We tested the hypothesis that environmental factors play a role in MC maturation in the skin. Methods: MCs were numerically, phenotypically, and functionally compared between germ‐free (GF), specific pathogen‐free, and GF mice reconstituted with microbiota. The maturity of MCs was… CONTINUE READING

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