Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration.

@article{Jacobs2006SkinIA,
  title={Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration.},
  author={John J. L. Jacobs and Cynthia L Leh{\'e} and Hitoshi Hasegawa and Graham R. Elliott and Pranab Kumar Das},
  journal={Experimental dermatology},
  year={2006},
  volume={15 6},
  pages={432-40}
}
Skin irritants and contact allergens reduce the number of Langerhans cells (LCs). It has been assumed that this reduction is due their migration to the draining lymph node (LN) for initiating immune sensitization in a host. Skin irritation, however, as opposed to contact allergy is not considered to be an immunological disease. Nevertheless, skin irritants are also known for their adjuvant-like effects on contact allergy, resulting in skin hypersensitivity reactions like toxic dermatitis. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Non-animal test methods for predicting skin sensitization potentials

Archives of Toxicology • 2012
View 9 Excerpts
Highly Influenced

Wet Work and Barrier Function.

Current problems in dermatology • 2016

Similar Papers

Loading similar papers…