Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis.

@article{Akiba2002SkinID,
  title={Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis.},
  author={Hitoshi Akiba and Jeanne Kehren and Marie-Th{\'e}r{\`e}se Ducluzeau and Maya Krasteva and Françoise Horand and Dominique Kaiserlian and Fumio Kaneko and Jean-françois Nicolas},
  journal={Journal of immunology},
  year={2002},
  volume={168 6},
  pages={3079-87}
}
Contact hypersensitivity (CHS) is a T cell-mediated, Ag-specific skin inflammation induced by skin exposure to haptens in sensitized individuals. Th1/T cytotoxic 1 cells are effector cells of CHS, whereas Th2/T regulatory CD4(+) T cells have down-regulating properties. We have previously shown that CHS to 2,4-dinitrofluorobenzene is mediated by specific CD8(+) effector cells, whose cytolytic activity is mandatory for induction of skin inflammation. In this study, using immunohistochemistry and… CONTINUE READING