Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: a possible role for regulatory T cells.

@article{Heimann2011SkininfiltratingTC,
  title={Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: a possible role for regulatory T cells.},
  author={Mareike Heimann and Jozef Janda and Ol{\"o}f G Sigurdard{\'o}ttir and Vilhj{\'a}lmur Svansson and Jolanta Klukowska and Claudia von Tscharner and Marcus G. Doherr and Hans Brostr{\"o}m and Lisa S. Andersson and Sigurj{\'o}n Einarsson and Eliane Marti and Sigurbj{\"o}rg Torsteinsd{\'o}ttir},
  journal={Veterinary immunology and immunopathology},
  year={2011},
  volume={140 1-2},
  pages={63-74}
}
Equine insect bite hypersensitivity (IBH) is a seasonally recurrent, pruritic skin disorder caused by an IgE-mediated reaction to salivary proteins of biting flies, predominantly of the genus Culicoides. The aim of this study was to define T cell subsets and cytokine profile in the skin of IBH-affected Icelandic horses with particular focus on the balance between T helper (Th) 1, Th2 and T regulatory (Treg) cells. Distribution and number of CD4+, CD8+ and Forkhead box P3 (FoxP3)+ T cells were… CONTINUE READING

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