Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.

@article{Accardi2006SkinHP,
  title={Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.},
  author={Rosita Accardi and Wen Dong and Anouk Smet and Rutao Cui and Agn{\`e}s H Hautefeuille and A Gabet and Bakary S. Sylla and Lutz Gissmann and Pierre Hainaut and Massimo Tommasino},
  journal={EMBO reports},
  year={2006},
  volume={7 3},
  pages={334-40}
}
The E6 and E7 of the cutaneous human papillomavirus (HPV) type 38 immortalize primary human keratinocytes, an event normally associated with the inactivation of pathways controlled by the tumour suppressor p53. Here, we show for the first time that HPV38 alters p53 functions. Expression of HPV38 E6 and E7 in human keratinocytes or in the skin of transgenic mice induces stabilization of wild-type p53. This selectively activates the transcription of deltaNp73, an isoform of the p53-related… CONTINUE READING