Skin exposure promotes a Th2-dependent sensitization to peanut allergens.

@article{Tordesillas2014SkinEP,
  title={Skin exposure promotes a Th2-dependent sensitization to peanut allergens.},
  author={Leticia Tordesillas and Ritobrata Goswami and Sara Bened{\'e} and Galina Grishina and David Dunkin and K M J{\"a}rvinen and Soheila J. Maleki and Hugh A Sampson and M Cecilia Berin},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 11},
  pages={4965-75}
}
Sensitization to foods often occurs in infancy, without a known prior oral exposure, suggesting that alternative exposure routes contribute to food allergy. Here, we tested the hypothesis that peanut proteins activate innate immune pathways in the skin that promote sensitization. We exposed mice to peanut protein extract on undamaged areas of skin and observed that repeated topical exposure to peanut allergens led to sensitization and anaphylaxis upon rechallenge. In mice, this epicutaneous… CONTINUE READING

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