Skin equivalent tensional force alters keloid fibroblast behavior and phenotype.

Abstract

Skin tension may influence keloid scar behavior, development, and spreading, e.g., butterfly-shaped keloid disease in the sternum. Here, we developed a three-dimensional (3D) in vitro model to mimic in vivo tension and evaluate keloid fibroblast (KF) behavior and extracellular matrix synthesis under tension. In vivo skin tension measured in volunteers (n… (More)
DOI: 10.1111/wrr.12215

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